You will find there's release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to lower afferent discomfort transmission and generate analgesia. For that reason, drugs like clonidine that goal alpha-2 receptors can affect the transmission of pain. Applies to clonidine: oral https://perryu062vyq0.blogoxo.com/profile