DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends via three nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated how https://eleanord912aun7.bleepblogs.com/profile